Glossary for the U.S. Transplant Data by Center Report

Disease Status

A measure of how the disease responded to treatment before the patient received a bone marrow or umbilical cord blood transplant.The disease status can help predict the likelihood of a better or worse survival outcome after transplantation.

In these reports, disease status is included only for leukemias and lymphomas.

Leukemia Disease Statuses


For chronic myelogenous leukemia (CML):
• 1st chronic phase—The disease responded well to treatment. There is no clinical evidence of leukemia.
• 2nd chronic phase or 1st accelerated phase—The disease recurred after responding well to initial treatment or progressed despite treatment.
  • 2nd chronic phase means there is no clinical evidence of the disease after further treatment.
  • 1st accelerated phase means the disease is progressing rapidly.
• Blast phase or other chronic leukemia disease state—The disease is not responding to treatment.
• Unknown—The disease status was not available.
For acute myleogenous leukemia (AML) or acute lymphoblastic leukemia (ALL):
• 1st remission—The disease responded well to treatment. There is no clinical evidence of leukemia.
• 2nd remission—The disease recurred after responding well to initial treatment. After further treatment, there is no clinical evidence of leukemia.
• Other acute leukemia disease state—The disease is not responding to treatment.
• Unknown—The disease status was not available.

Lymphoma Disease Statuses

• In remission—The disease responded well to treatment. There is no clinical evidence of lymphoma.
• Not in remission—The disease is not responding to treatment. There is still some evidence of lymphoma.
• Unknown—The disease status was not available.

Donor Type

Biological relationship between the patient and the donor who provided the blood-forming cells.

• Autologous—The patient's own cells were collected.
• Allogeneic—A volunteer donated bone marrow, peripheral blood, or an umbilical cord blood unit. These cells match the patient’s human leukocyte antigen (HLA) type. Specific allogeneic types include:
  
  
  • HLA-matched sibling—The brother or sister who donated cells is the patient's biological sibling.
  • Other related—The family member who donated cells is related biologically to the patient.
  • Unrelated—The person who donated cells is not related biologically to the patient.

Human Leukocyte Antigen (HLA)

Proteins on cells that make each person's tissue unique.

HLA typing is used to match patients and donors for a bone marrow or umbilical cord blood transplant. (A person's HLA type is identified by testing a blood sample or swab of cheek cells.)