Each year, thousands of people are diagnosed with leukemia, lymphoma, or certain immune system or genetic metabolic disorder. Many of these patients need an umbilical cord blood or bone marrow transplant (also called a BMT). Because the qualities that make a suitable match for bone marrow or umbilical cord blood are inherited, a match from a sibling or other family member is often checked first. However, 70 percent of patients will not find a matching donor in their family. For these patients, a transplant of bone marrow or cord blood from an unrelated donor may be their only transplant option.
A bone marrow or cord blood transplant replaces diseased blood-forming cells with healthy cells. Cells for a transplant can come from the marrow of a donor or from the blood of the umbilical cord collected after a baby is born. Sometimes special qualities of umbilical cord blood make it a better choice of blood-forming cells for transplant.
The United States Congress saw the need to help more patients who need a bone marrow or cord blood transplant and passed the Stem Cell Therapeutic and Research Act of 2005, Public Law 109-129 (Stem Cell Act 2005) and the Stem Cell Therapeutic and Research Reauthorization Acts of 2010 and 2015, Public Laws 111-264 (Stem Cell Act 2010) and 114-101 (Stem Cell Act of 2015). These acts include support for umbilical cord blood transplant and research.
Learn how umbilical cord blood may be helpful and how the Stem Cell Acts of 2005 and 2010 are helping patients.
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The chances of a successful bone marrow or cord blood transplant are better when the blood-forming cells are from a donor who closely matches the patient. However, studies show that cord blood may not need to match as closely as is necessary for a marrow donor. Umbilical cord blood may be especially promising for:
To learn about matching blood-forming cells for a transplant, see HLA Matching: Finding the Best Donor or Cord Blood Unit.
Although cord blood can help patients who cannot find a well-matched marrow donor, matching is still important. Cord blood is especially needed from communities such as:
Umbilical cord blood may help more people from many diverse racial and ethnic communities have a second chance at life.
The Stem Cell Acts of 2005, 2010 and 2015 help patients who have life-threatening diseases and may need a cord blood or marrow transplant. These acts:
One part of the Program, the Cord Blood Coordinating Center, has a network of cord blood banks, including some banks that get Federal support to build the NCBI. The Cord Blood Coordinating Center works with its network of cord blood banks to recruit expectant parents for umbilical cord blood donations and to distribute cord blood units listed on the registry of the C.W. Bill Young Cell Transplantation Program, also called the Be The Match Registry®. The registry is a listing of potential marrow donors and donated cord blood units.
Learn how patients who need a transplant are being given hope by the Be the Match Registry.
Having more cord blood units available through the NCBI and the Cord Blood Coordinating Center means that more patients have a better chance of receiving a potentially life-saving transplant.
See if your hospital collects cord blood for public donation and then contact the listed public cord blood bank to determine your eligibility.